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Better Treatment, Better Outcomes

The Nano Research Facility (NRF) Partners with medical company in the fight against strokes



Stroke is the third leading cause of death in America, but Pulse Therapeutics, Inc., a St. Louis-based medical device company, is working to change that. Of paramount importance in the fight against strokes is the innovation of more effective treatment technologies. That is why Pulse Therapeutics, in partnership with Washington University’s Nano Research Facility (NRF), is developing an emergency room technology to improve stroke outcomes in patients. This technology mechanically amplifies the effects of clot-busting drugs in the treatment of stroke using an external magnetic field coupled to magnetic nanoparticles at the site of the clot.


"The Nano Research Facility at Washington University has assisted the work of Pulse Therapeutics since the earliest days of the company," says Michael Sabo, senior director of R&D at Pulse Therapeutics, Inc. The project, which is being funded by the National Institutes of Health, is ongoing. "The people of NRF have been a pleasure to work with and have continuously exhibited the highest level of technical competence, courteousness, and professionalism," he continues.


Sabo adds: "NRF has played a critical role through all stages of our product development from nanoparticle synthesis and technology transfer, to characterization of size and coating thickness, through the continuous measurements of key efficacy markers during preclinical and clinical studies."


In this past year, Pulse Therapeutics has successfully completed enrollment in its first human pilot study in Australia. The trial focused on using magnetomotive enhanced thrombolysis in patients suffering an ischemic stroke. Ischemic stroke affect 700,000 Americans each year. During this trial, nanoparticle samples were characterized using the facilities at NRF. Pulse has continued to look at innovative applications of the magnetomotive technology and several additional experiments were conducted at NRF to collect additional data in support of NIH SBIR grant applications.